Over the past few years, the Ekaterinburg (Russia) interdisciplinary nanotoxicological research team has carried out a series of investigations using different in vivo and in vitro experimental models in order to elucidate the cytotoxicity and organ-systemic and organism-level toxicity of lead-containing nanoparticles (NP) acting separately or in combinations with some other metallic NPs. The authors claim that their many-sided experience in this field is unique and that some of their important results have been obtained for the first time. This paper is an overview of the team’s previous publications in different journals. It is suggested to be used as a compact scientific base for assessing health risks associated not only with the production and usage of engineered lead-containing NPs but also with their inevitable by-production as toxic air pollutants in the metallurgy of lead, copper or their alloys and in soldering operations.

在过去的几年中，叶卡捷琳堡（俄罗斯）跨学科纳米毒理学研究团队使用不同的体内和体外进行了一系列研究实验模型，以阐明含铅纳米颗粒（NP）单独或与某些其他金属NP组合使用时的细胞毒性以及器官系统和生物体水平的毒性。作者声称，他们在这一领域的多方面经验是独特的，并且他们的一些重要成果是第一次获得的。本文概述了该团队以前在不同期刊上发表的文章。建议将其用作评估科学风险的紧凑科学依据，这些风险不仅与工程和含铅的NP的生产和使用有关，而且与在铅，铜或铜的冶金中作为有毒空气污染物不可避免地产生的副产物有关合金和焊接操作中。