Abstract A new Co(II)-containing coordination polymer formulated as [Co(H-ntb)]n (1) has been synthesized via reaction of Co(NO3)2·6H2O with the 4,4′,4′’-nitrilotribenzoate (H3ntb) ligand under solvothermal conditions. In addition, the enhancement of the compound on Fentanyl analgesic activity was evaluated. First, the RT-PCR was carried out to assess the glutamate receptor relative expression level on sympathetic nerve cells. Then, the mouse hot plate analgesic experiment was performed for the evaluation of the enhancement of the compound on Fentanyl analgesic activity. In the end, molecular docking simulation has been performed to investigate the possible interactions between the probe protein and the Co(II) complex. Graphical Abstract

中文翻译：

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Co(II) 配位聚合物：通过降低谷氨酸受体表达增强芬太尼镇痛活性

摘要 通过 Co(NO3)2·6H2O 与 4,4',4''-次氮基三苯甲酸酯反应合成了一种新的含 Co(II) 配位聚合物 [Co(H-ntb)]n (1)。 (H3ntb) 配体在溶剂热条件下。此外，还评估了化合物对芬太尼镇痛活性的增强作用。首先，进行RT-PCR以评估交感神经细胞上谷氨酸受体的相对表达水平。然后，进行小鼠热板镇痛实验，以评价该化合物对芬太尼镇痛活性的增强作用。最后，进行了分子对接模拟，以研究探针蛋白与 Co(II) 复合物之间可能的相互作用。图形概要