Abstract

A green protocol for the synthesis of unsubstituted imidazoles has been demonstrated herein. The reaction is realized using commercially available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions are selective and mild which helped to tolerate a wide variety of functional groups to give the desired products in good chemical yields.

中文翻译：

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在环境条件下在水中三组分合成未取代的 1H-咪唑的可持续方法

摘要

本文展示了一种用于合成未取代咪唑的绿色方案。该反应是使用市售脂肪酶、猪胰腺脂肪酶 (PPL) 在水中实现的。反应条件具有选择性和温和性，有助于耐受多种官能团，从而以良好的化学产率得到所需的产物。