Pseudomonas aeruginosa and Serratia marcescens are prominent members belonging to the group of ESKAPE pathogens responsible for Urinary Tract Infections (UTI) and nosocomial infections. Both the pathogens regulate several virulence factors, including biofilm formation through quorum sensing (QS), an intercellular communication mechanism. The present study describes the anti-biofilm and QS quenching effect of thiazolinyl-picolinamide based palladium(II) complexes against P. aeruginosa and S. marcescens. Palladium(II) complexes showed quorum sensing inhibitory potential in inhibiting swarming motility behaviour, pyocyanin production and other QS mediated virulence factors in both P. aeruginosa and S. marcescens. In addition, the establishment of biofilms was prevented on palladium (II) coated catheters. Overall, the present study demonstrates that thiazolinyl-picolinamide based palladium (II) complexes will be a promising strategy to combat device-mediated UTI infections.

铜绿假单胞菌和粘质沙雷氏菌是ESKAPE病原体的主要成员，这些病原体负责尿路感染（UTI）和医院感染。两种病原体均调节几种毒力因子，包括通过群体感应（QS）（一种细胞间通讯机制）形成生物膜。本研究描述了基于噻唑啉基-吡啶甲酸酰胺的钯（II）配合物对铜绿假单胞菌和粘菌链霉菌的抗生物膜和QS猝灭作用。钯（II）配合物在铜绿假单胞菌和铜绿假单胞菌中均表现出群体感应抑制潜力，可抑制群体运动行为，绿脓素生成和其他QS介导的毒力因子。葡萄球菌。此外，防止了在涂有钯（II）的导管上建立生物膜。总体而言，本研究表明，基于噻唑啉基-吡啶甲酰胺的钯（II）配合物将成为对抗设备介导的UTI感染的有前途的策略。