ABSTRACT The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model.

中文翻译：

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假手术胚胎移植影响 ISIAH 大鼠子代神经发育和高血压表型的表现

摘要 该研究调查了妊娠期间的手术，即与胚胎移植相关的假手术，如何影响具有高血压遗传倾向的 ISIAH 大鼠的高血压表型。将在怀孕第四天母体手术后出生的 ISIAH 大鼠与自然受孕的对照组进行比较。ISIAH 大鼠妊娠期手术导致年轻后代神经发育加速，并加重高血压，抑制探索活动，降低海马 BDNF 表达，并代偿性增加成年 ISIAH 后代的海马神经元密度。妊娠早期母体手术导致高血压 ISIAH 大鼠模型中后代表型的改变。