Central nervous system high-grade neuroepithelial tumour with MN1 alteration (CNS HGNET-MN1) is a brain tumour methylation class that has recently been identified, based on (epi)genetic profiles of a large CNS-PNETs cohort [1]. This class is characterized by MN1 gene rearrangements, with BEND2 being the most frequently reported fusion partner [1]. Histologically, tumours of this class show pseudopapillary architecture and dense stromal hyalinization [1], features characteristic of astroblastoma. The majority of cases within CNS HGNET-MN1 are represented by the latter, though histopathological aspects resembling ependymomas and not otherwise specified tumours may also be encountered [2]. It remains uncertain, however, if MN1 alterations are an exclusive anomaly of CNS HGNET-MN1.

中文翻译：

---

一种多表型恶性儿童脑肿瘤，表现为 MN1-PATZ1 融合，与具有 MN1 改变的 CNS 高级别神经上皮肿瘤 (CNS HGNET-MN1) 没有表观遗传相似性，并且与 PATZ1 融合肉瘤相关

具有 MN1 改变的中枢神经系统高级神经上皮肿瘤 (CNS HGNET-MN1) 是最近根据大型 CNS-PNET 队列的（表观）遗传谱确定的一种脑肿瘤甲基化类型 [1]。此类的特点是 MN1 基因重排，其中 BEND2 是最常报道的融合伙伴 [1]。在组织学上，此类肿瘤显示出假乳头状结构和致密的间质透明化 [1]，具有星形母细胞瘤的特征。CNS HGNET-MN1 中的大多数病例由后者代表，尽管也可能遇到类似于室管膜瘤和未指定肿瘤的组织病理学方面 [2]。然而，仍然不确定 MN1 的改变是否是 CNS HGNET-MN1 的独有异常。