CCR9 and CCL25: A review of their roles in tumor promotion.,Journal of Cellular Physiology

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CCR9 and CCL25: A review of their roles in tumor promotion.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-13 , DOI: 10.1002/jcp.29782
Baoping Xu ₁ , Chao Deng ₂ , Xue Wu ₁ , Ting Ji ₁ , Lin Zhao ₃ , Yuehu Han ₃ , Wenwen Yang ₁ , Yating Qi ₁ , Zheng Wang ₄ , Zhi Yang ₁ , Yang Yang ₁

Affiliation

Chemokines constitute a superfamily of small chemotactic cytokines with functions that are based on interactions with their corresponding receptors. It has been found that, among other functions, chemokines regulate the migratory and invasive abilities of cancer cells. Multiple studies have confirmed that chemokine receptor 9 (CCR9) and its exclusive ligand, chemokine 25 (CCL25), are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This review evaluates recent advances in understanding the role of CCR9/CCL25 in cancer development. First, we outline the general background of chemokines in cancer and the structure and function of CCR9 and CCL25. Next, we describe the basic function of CCR9/CCL25 in the cancer process. Then, we introduce the role of CCR9/CCL25 and related signaling pathways in various cancers. Finally, future research directions are proposed. In general, this paper is intended to serve as a comprehensive repository of information on this topic and is expected to contribute to the design of other research projects and future efforts to develop treatment strategies for ameliorating the effects of CCR9/CCL25 in cancer.

中文翻译：

CCR9和CCL25：综述其在肿瘤促进中的作用。

趋化因子构成小趋化性细胞因子的超家族，其功能基于与其相应受体的相互作用。已经发现，除其他功能外，趋化因子调节癌细胞的迁移和侵袭能力。多项研究已证实趋化因子受体9（CCR9）及其唯一配体趋化因子25（CCL25）在多种恶性肿瘤中过表达，并且与肿瘤增殖，凋亡，侵袭，迁移和耐药性密切相关。这篇综述评估了了解CCR9 / CCL25在癌症发展中的作用的最新进展。首先，我们概述了趋化因子在癌症中的一般背景以及CCR9和CCL25的结构和功能。接下来，我们描述CCR9 / CCL25在癌症过程中的基本功能。然后，我们介绍了CCR9 / CCL25和相关信号通路在各种癌症中的作用。最后，提出了今后的研究方向。总体而言，本文旨在作为该主题的综合信息存储库，并有望为其他研究项目的设计和未来的努力，以开发改善CCR9 / CCL25在癌症中作用的治疗策略做出贡献。

更新日期：2020-05-13

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