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Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations.
Annals of the New York Academy of Sciences ( IF 4.295 ) Pub Date : 2020-05-13 , DOI: 10.1111/nyas.14366
Miles J Klimara,Derrick R Randall,Jacqueline Allen,Edgar Figueredo,Nikki Johnston

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.
更新日期:2020-05-13

 

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