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Recent Trends in Electrochemical Sensors for Vital Biomedical Markers Using Hybrid Nanostructured Materials.
Advanced Science ( IF 14.3 ) Pub Date : 2020-05-12 , DOI: 10.1002/advs.201902980
K Koteshwara Reddy 1, 2 , Harshad Bandal 1 , Moru Satyanarayana 3 , Kotagiri Yugender Goud 3 , Kauveri Vengatajalabathy Gobi 3 , Tippabattini Jayaramudu 2 , John Amalraj 2 , Hern Kim 1
Affiliation  

This work provides a succinct insight into the recent developments in electrochemical quantification of vital biomedical markers using hybrid metallic composite nanostructures. After a brief introduction to the biomarkers, five types of crucial biomarkers, which require timely and periodical monitoring, are shortlisted, namely, cancer, cardiac, inflammatory, diabetic and renal biomarkers. This review emphasizes the usage and advantages of hybrid nanostructured materials as the recognition matrices toward the detection of vital biomarkers. Different transduction methods (fluorescence, electrophoresis, chemiluminescence, electrochemiluminescence, surface plasmon resonance, surface‐enhanced Raman spectroscopy) reported for the biomarkers are discussed comprehensively to present an overview of the current research works. Recent advancements in the electrochemical (amperometric, voltammetric, and impedimetric) sensor systems constructed with metal nanoparticle‐derived hybrid composite nanostructures toward the selective detection of chosen vital biomarkers are specifically analyzed. It describes the challenges involved and the strategies reported for the development of selective, sensitive, and disposable electrochemical biosensors with the details of fabrication, functionalization, and applications of hybrid metallic composite nanostructures.

中文翻译:

使用混合纳米结构材料的重要生物医学标记物电化学传感器的最新趋势。

这项工作为利用混合金属复合纳米结构对重要生物医学标记物进行电化学定量的最新进展提供了简洁的见解。在对生物标志物进行简要介绍后,我们列出了五类需要及时定期监测的关键生物标志物,即癌症、心脏、炎症、糖尿病和肾脏生物标志物。本综述强调了混合纳米结构材料作为检测重要生物标志物的识别基质的用途和优势。全面讨论了生物标志物报道的不同转导方法(荧光、电泳、化学发光、电化学发光、表面等离子体共振、表面增强拉曼光谱),以概述当前的研究工作。专门分析了使用金属纳米粒子衍生的混合复合纳米结构构建的电化学(电流、伏安和阻抗)传感器系统的最新进展,以选择性检测选定的重要生物标志物。它描述了开发选择性、灵敏和一次性电化学生物传感器所面临的挑战和报告的策略,并详细介绍了混合金属复合纳米结构的制造、功能化和应用。
更新日期:2020-07-08
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