Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both initiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa and are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we focused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa. Specifically, we summarized recent pieces of evidence about lncRNAs NEAT1, H19, MALAT1, and HOTAIR, in estrogen signaling, emphasizing their role in PCa progression and the acquisition of a castration-resistant phenotype. Here, the reader will find information about lncRNAs present in estrogen-dependent transcriptional complexes. The potential role of lncRNA/estrogen signaling as a novel pathway for PCa treatment will be discussed.

中文翻译：

---

通过雌激素受体的信号调节前列腺癌中的长非编码RNA。

前列腺癌（PCa）是一种性激素依赖型癌症，其中雌激素在引发和进展中均起关键作用。最近，一些长的非编码RNA（lncRNA）与PCa相关，据推测在这类癌症的生物学和进展中起着关键作用。在这篇综述中，我们重点研究了一些在PCa中以雄激素和雌激素转录反应性着称的lncRNA。具体而言，我们总结了有关lncRNA NEAT1，H19，MALAT1和HOTAIR在雌激素信号传导中的最新证据，强调它们在PCa进程中的作用以及去势抵抗性表型的获得。在这里，读者将找到有关存在于雌激素依赖性转录复合物中的lncRNA的信息。