Mosquito vectors in the genera Anopheles, Aedes, and Culex transmit a variety of medically important pathogens. Current vector control tools are reaching the limits of their effectiveness, necessitating the introduction of innovative vector control technologies. RNAi, which facilitates functional characterization of mosquito genes in the laboratory, could one day be applied as a new method of vector control. Recent advances in the oral administration of microbial-based systems for delivery of species-specific interfering RNA pesticides to mosquitoes may facilitate translation of this technology to the field. Oral RNAi-based pesticides represent a new class of biorational pesticides that could combat increased global incidence of insecticide resistance and which could one day become critical components of integrated human disease vector mosquito control programs.

按蚊属、伊蚊属和库蚊属的蚊媒传播多种医学上重要的病原体。当前的矢量控制工具已达到其有效性的极限，因此需要引入创新的矢量控制技术。 RNAi 有助于在实验室中对蚊子基因进行功能表征，有一天可能会成为一种新的病媒控制方法。最近在基于微生物的口服系统向蚊子递送物种特异性干扰 RNA 杀虫剂方面取得的进展可能有助于将该技术转化为实际应用。基于口服 RNAi 的杀虫剂代表了一类新型生物合理杀虫剂，可以对抗全球范围内日益增加的杀虫剂抗药性，并且有朝一日可能成为人类疾病媒介蚊子综合控制计划的关键组成部分。