Abstract Dendrimers are having novel three dimensional, synthetic hyperbranched, nano-polymeric structure. Among all of the dendrimers, Poly-amidoamine (PAMAM) dendrimer are used enormously applying materials in supramolecular chemistry. This review described the structure, characteristic, synthesis, toxicity, and surface modification of PAMAM dendrimer. Various strategies in supramolecular chemistry of PAMAM for synthesizing it at commercial and laboratory scales along with their limitations and applications has also discussed. When compared to other nano polymers, the characteristics of supramolecular PAMAM dendrimers in nanopolymer science has shown significant achievement in transporting drugs for molecular targeted therapy, particularly in host–guest reaction. It also finds its applications in gene transfer devices and imaging of biological systems with minimum cytotoxicity. From that viewpoint, this review has elaborated the structural and safety aspect of PAMAM for targeted drug delivery with pharmaceuticals in addition to the biomedical application.

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Starburst pamam 树枝状聚合物：合成方法、表面改性和生物医学应用

摘要 树枝状大分子具有新颖的三维合成超支化纳米聚合物结构。在所有的树枝状大分子中，聚酰氨基胺（PAMAM）树枝状大分子在超分子化学材料中的应用非常广泛。该综述描述了PAMAM树枝状聚合物的结构、特性、合成、毒性和表面改性。还讨论了在商业和实验室规模合成 PAMAM 超分子化学的各种策略及其局限性和应用。与其他纳米聚合物相比，纳米聚合物科学中超分子 PAMAM 树枝状大分子的特性在分子靶向治疗药物转运方面取得了重大成就，尤其是在主客体反应中。它还在基因转移装置和具有最小细胞毒性的生物系统成像中得到应用。从这个角度来看，本综述详细阐述了 PAMAM 的结构和安全性方面，除了生物医学应用外，还用于药物靶向给药。