Pleural fluid (PF) immune response in anergic tuberculous pleural effusion (TPE) patients is poorly understood. This study aimed to compare PF biochemical parameters and chemokine levels between anergic and non-anergic TPE patients. Chemokine arrays, cytokine measurements, and flow cytometry were performed in 58 patients (TPE [non-anergic (n = 32) and anergic (n = 10)] and malignant pleural effusion (MPE) [n = 16]). PF adenosine deaminase 2 (ADA2) levels were significantly lower in anergic TPE patients than in non-anergic TPE patients (p = 0.048). Among the 40 chemokines tested, PF CCL27 levels were significantly higher in anergic TPE patients than in non-anergic TPE and MPE patients (p < 0.001). The percentage of CD4+CCR10+T cells in PF was higher in anergic TPE patients than in non-anergic TPE and MPE patients (p = 0.001). We reported here that CCL27/CCR10 interactions might contribute to pathophysiology in anergic TPE. PF CCL27 and CD4+CCR10+T cells may help in diagnosing TPE in patients with moderate elevation of PF ADA levels.

中文翻译：

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无能与非无能结核性胸腔积液患者胸水​​生化指标及趋化因子水平比较

对无反应性结核性胸腔积液 (TPE) 患者的胸水 (PF) 免疫反应知之甚少。本研究旨在比较无反应性和非无反应性 TPE 患者的 PF 生化参数和趋化因子水平。在 58 名患者（TPE [非无反应性（n = 32）和无反应性（n = 10）] 和恶性胸腔积液（MPE）[n = 16]）中进行了趋化因子阵列、细胞因子测量和流式细胞术。无反应性 TPE 患者的 PF 腺苷脱氨酶 2 (ADA2) 水平显着低于非无反应性 TPE 患者 (p = 0.048)。在测试的 40 种趋化因子中，无反应性 TPE 患者的 PF CCL27 水平显着高于非无反应性 TPE 和 MPE 患者（p < 0.001）。PF 中 CD4+CCR10+T 细胞的百分比在无反应性 TPE 患者中高于非无反应性 TPE 和 MPE 患者（p = 0.001）。我们在这里报告了 CCL27/CCR10 相互作用可能有助于无能 TPE 的病理生理学。PF CCL27 和 CD4+CCR10+T 细胞可能有助于诊断 PF ADA 水平中度升高的患者的 TPE。