Cannabis has been used as a medicine for millennia. Crude extracts of cannabis inflorescence contain numerous phytomolecules, including phytocannabinoids, terpenes, and flavonoids. Combinations of phytomolecules have been recently established as superior to the use of single molecules in medical treatment owing to the ‘entourage effect’. Two types of entourage effects are defined: ‘intra-entourage', resulting from interactions among phytocannabinoids or terpenes, and ‘inter-entourage', attributed to interactions between phytocannabinoids and terpenes. It is suggested that the phytomolecule assemblages found in cannabis chemovars today derive from selective breeding during ancient cultivation. We propose that the current cannabis chemotaxonomy should be redefined according to chemical content and medicinal activity. In parallel, combinations of phytomolecules that exhibit entourage activity should be explored further for future drug development.

大麻已被用作药物已有数千年的历史了。大麻花序的粗提取物含有许多植物分子，包括植物大麻素，萜烯和类黄酮。由于“吸收作用”，最近已经确定了植物分子的组合优于在治疗中使用单分子。定义了两种随行效应：“植物内部”是由于植物大麻素或萜烯之间的相互作用而产生的，而“相互”是由于植物大麻素与萜烯之间的相互作用而产生的。有人建议，当今在大麻化石中发现的植物分子组合来自古代栽培期间的选择性繁殖。我们建议应根据化学含量和药物活性重新定义当前的大麻化学分类法。在平行下，