While cognition and depression have often been studied in patients with epilepsy, only a few studies have so far attempted to link these two domains, and more specifically to investigate the specific impact of depression on cognition in epilepsy. In this review, we performed an extensive search of the literature database to provide a better understanding of this subject. Using several inclusion criteria (adult population, quantitative depression/neuropsychological assessment, statistical analyses of the impact of depression on cognitive scores, patients with epilepsy (PWE) and no other neurological disease, and studies including at least 20 patients), we identified 20 articles (out of 712 search results) that investigated both depression and cognition in PWE. Their results were summarized using a narrative and descriptive approach. This review highlights a variable impact of depression on cognition in PWE, depending on the laterality of the seizure onset zone, the type of epilepsy and the surgical context. We emphasize the need for a systematic depression assessment in these patients, especially since depressed PWE will benefit from prompt and appropriate care to help them avoid cognitive decline, particularly in a surgical context.

尽管通常在癫痫患者中进行认知和抑郁的研究，但到目前为止，仅有少数研究尝试将这两个领域联系起来，更具体地说，是研究抑郁对癫痫认知的具体影响。在这篇评论中，我们对文献数据库进行了广泛的搜索，以更好地理解这一主题。使用几种纳入标准（成人人群，定量抑郁/神经心理评估，抑郁对认知评分的影响的统计分析，患有癫痫（PWE）且无其他神经系统疾病的患者以及包括至少20例患者的研究），我们确定了20篇文章（从712个搜索结果中）调查了PWE中的抑郁和认知能力。他们的结果使用叙述性和描述性方法进行了总结。这篇综述强调了抑郁症对PWE认知的影响，这取决于癫痫发作区的偏侧性，癫痫的类型和手术环境。我们强调需要对这些患者进行系统的抑郁评估，尤其是因为抑郁的PWE将受益于及时而适当的护理，以帮助他们避免认知能力下降，尤其是在外科手术中。