Toxoplasma gondii (T. gondii) causes chronic, latent infections of global concern. Its subclinical influence on behavior and cognition are poorly understood. The objective of this research is to determine the relationship of T. gondii IgG with cognition using National Health and Nutrition Examination Survey data, 2013–2014 in older adults ≥60 years. A composite cognitive function score was created by adding the scores of the memory test, language/verbal fluency, and working memory test. T. gondii IgG was dichotomized at <33 IU/mL (negative) and ≥33 IU/mL (positive). There were 19.2% of the participants who were T. gondii IgG⁺. The memory function and language/verbal fluency subtests failed to reach significance; however, the difference in the working memory test was significant. In the multivariable ordinal logistic regression analysis, controlling for potential confounders, the odds of cognitive function scores decreasing in quartiles among people with positive vs. negative T. gondii IgG are 1.55 (95% CI: 1.08, 2.21; p = .0170). Establishing an evidence base for the association of T. gondii IgG and cognition is complex, but essential.

弓形虫（ T. gondii ）引起全球关注的慢性、潜伏感染。人们对它对行为和认知的亚临床影响知之甚少。本研究的目的是利用 2013 年至 2014 年 60 岁以上老年人的国家健康和营养检查调查数据来确定弓形虫IgG 与认知的关系。通过将记忆测试、语言/言语流畅性和工作记忆测试的分数相加来创建综合认知功能分数。刚地弓形虫IgG在<33 id=124>T处二分。弓形虫 IgG ⁺ .记忆功能和语言/言语流畅性分项测试未能达到显着性；然而，工作记忆测试的差异却很大。在多变量有序 Logistic 回归分析中，控制潜在的混杂因素，弓形虫IgG 阳性与阴性人群认知功能得分四分位数下降的几率为 1.55 (95% CI: 1.08, 2.21; p = .0170)。建立弓形虫IgG 与认知之间关系的证据基础很复杂，但很重要。