当前位置: X-MOL 学术J. Neurosci. Methods › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Protocols for instrumental memory reconsolidation in rodents: A methodological review.
Journal of Neuroscience Methods ( IF 2.7 ) Pub Date : 2020-05-12 , DOI: 10.1016/j.jneumeth.2020.108766
Alessandro Piva 1 , Nicholas Pintori 1 , Laura Padovani 1 , Cristiano Chiamulera 1
Affiliation  

BACKGROUND Memory reconsolidation enables the update of a previously consolidated memory trace after its reactivation. Although Pavlovian memory reconsolidation has been widely demonstrated, instrumental memory reconsolidation is still debated. Early studies suggested that instrumental memories did not undergo reconsolidation and therefore could not be disrupted, whereas other authors suggested that these memories are just more resistant to destabilization and reconsolidation in comparison to Pavlovian memories. AIM AND RESULTS The present paper reviews the behavioural protocols used to investigate appetitive instrumental memory reconsolidation in rodents and describes in detail the specific methods used for memory retrieval, with a critical analysis of the different experimental parameters. CONCLUSIONS The modalities under which the reconsolidation of appetitive (sucrose or drugs of abuse) instrumental memories occurs have been explored and partially elucidated. Further investigations are recommended on the boundary conditions that constrain instrumental memory reactivation.

中文翻译:

啮齿动物工具记忆整合的协议:方法学综述。

背景技术存储器重新合并使得能够在重新激活之后更新先前合并的存储器跟踪。尽管已经广泛证明了巴甫洛夫式记忆的重新整合,但对工具性记忆的重新整合仍存在争议。早期研究表明,工具性记忆没有经过重新整合,因此不能被破坏,而其他作者则认为,与巴甫洛夫式记忆相比,这些记忆更能抵抗不稳定和重新整合。目的和结果本论文综述了用于研究啮齿动物中的食性工具性记忆巩固的行为方案,并详细描述了用于记忆检索的特定方法,并对不同的实验参数进行了严格的分析。结论已经探索并部分阐明了重新整合食性(蔗糖或滥用药物)工具性记忆的方式。建议对限制仪器记忆重新激活的边界条件进行进一步研究。
更新日期:2020-05-13
down
wechat
bug