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The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis.
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-05-13 , DOI: 10.1016/j.chom.2020.04.014 David L Sacks 1
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-05-13 , DOI: 10.1016/j.chom.2020.04.014 David L Sacks 1
Affiliation
The phagosomal pathogen Leishmania appears unaffected by deliberate changes in the early Th1/Th2 balance. In this issue, Carneiro et al. explain these paradoxical results by showing that manipulations affecting IFN-γ-mediated phagocyte activation are counteracted by effects on IFN-γ-dependent recruitment of CCR2+ monocytes permissive to parasite growth.
中文翻译:
利什曼病中IFN-γ的无效假说和单核细胞功能。
吞噬体病原体利什曼原虫似乎不受Th1 / Th2早期平衡的故意改变的影响。在本期中,Carneiro等人。通过显示影响IFN-γ介导的吞噬细胞激活的操作被对IFN-γ依赖性CCR2 +单核细胞允许寄生虫生长的募集作用抵消,从而解释了这些矛盾的结果。
更新日期:2020-05-13
中文翻译:
利什曼病中IFN-γ的无效假说和单核细胞功能。
吞噬体病原体利什曼原虫似乎不受Th1 / Th2早期平衡的故意改变的影响。在本期中,Carneiro等人。通过显示影响IFN-γ介导的吞噬细胞激活的操作被对IFN-γ依赖性CCR2 +单核细胞允许寄生虫生长的募集作用抵消,从而解释了这些矛盾的结果。