As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design." We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses including HIV and influenza, as well as coronaviruses.

中文翻译：

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COVID-19时代的合理疫苗设计。

当科学家考虑SARS-CoV-2疫苗设计时，我们讨论了可能遇到的问题以及如何通过我们所谓的“合理疫苗设计”解决这些问题。我们进一步讨论了泛冠状病毒疫苗的方法。我们借鉴最近对几种病毒（包括HIV和流感以及冠状病毒）的研究经验。