The rapid emergence of a highly pathogenic, readily transmissible coronavirus has resulted in a global pandemic, affecting millions and destabilizing economies. This catastrophe triggered a clarion call for the immediate deployment of a protective vaccine. We describe the unique challenges of developing a vaccine against SARS-CoV-2 in a pandemic setting.

中文翻译：

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大流行期间针对新病毒的疫苗开发面临的挑战。

高致病性，易于传播的冠状病毒迅速出现，导致了全球大流行，影响了数百万人并破坏了经济。这场灾难引发了号召，要求立即部署保护性疫苗。我们描述了在大流行环境中开发针对SARS-CoV-2疫苗的独特挑战。