Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma.,Applied Radiation and Isotopes

当前位置： X-MOL 学术 › Appl. Radiat. Isot. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma.
Applied Radiation and Isotopes ( IF 1.6 ) Pub Date : 2020-05-13 , DOI: 10.1016/j.apradiso.2020.109202
Hironobu Yanagie ₁ , Masashi Yanagawa ₂ , Tsuyoshi Higuchi ₃ , Ryouji Mizumachi ₃ , Mitsuteru Fujihara ₄ , Yasuyuki Morishita ₅ , Yuriko Sakurai ₆ , Kikue Mouri ₆ , Novriana Dewi ₆ , Yasumasa Nonaka ₇ , Atsuko Shinohara ₈ , Takehisa Matsukawa ₉ , Ayano Kubota ₉ , Kazuhito Yokoyama ₉ , Minoru Suzuki ₁₀ , Shin-Ichiro Masunaga ₁₀ , Yohinori Sakurai ₁₀ , Hiroki Tanaka ₁₀ , Koji Ono ₁₁ , Haruo Yamauchi ₁₂ , Minoru Ono ₁₂ , Jun Nakajima ₁₃ , Shushi Higashi ₁₄ , Hiroyuki Takahashi ₁₅

Affiliation

Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, 113-8655, Japan; Research Institute of Healthy Living, Niigata University of Pharmacy & Applied Life Sciences, Niigata, 956-8603, Japan.
Veterinary Medical Center, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, 080-8555, Japan.
Department of Pharmacology, Kumamoto Institute Branch, LSI Medience Ltd. Co., Kumamoto, 869-0425, Japan.
SPG Techno Ltd. Co., Miyazaki, 880-0303, Japan.
Department of Human & Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, 113-8655, Japan; Research Institute of Healthy Living, Niigata University of Pharmacy & Applied Life Sciences, Niigata, 956-8603, Japan.
Department of Surgery, Keiai-kai Hoyo Hospital, Iwate, 028-3111, Japan.
Department of Humanities, The Graduate School of Seisen University, Tokyo, 141-8642, Japan; Department of Hygiene, Faculty of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Department of Hygiene, Faculty of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Kyoto Univ Institute for Integrated Radiation & Nuclear Science, Osaka, 590-0494, Japan.
Kansai BNCT Medical Center, Osaka Medical College, Osaka, 569-8686, Japan.
Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, 113-8655, Japan; Department of Cardiac Surgery, The University of Tokyo Hospital, Tokyo, 113-8655, Japan.
Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, 113-8655, Japan; Department of Pulmonary Surgery, The University of Tokyo Hospital, Tokyo, 113-8655, Japan.
Department of Surgery, Kojin-kai Medicalcity East Hospital, Miyazaki, 885-0035, Japan.
Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, 113-8655, Japan.

We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as ¹⁰B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of ¹⁰BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of ¹⁰B compound as multidisciplinary treatments for HCC.

中文翻译：

通过动脉内注射 10BSH 包埋的水包油包水乳剂进行硼中子俘获治疗肝细胞癌的单剂量毒性研究。

我们开发了一种混合医疗设备，通过附着 Shirasu 多孔玻璃 Millipore 膜，在更短的时间内制备水包油包水 (WOW) 乳液，作为包埋¹⁰ B 的 WOW 乳液应用于肝细胞癌 (HCC) 治疗。在兔和猪中通过动脉内注射^{10 个}BSH 包裹的 WOW 进行了单剂量毒性研究，没有观察到副作用。我们希望继续进行临床前和临床研究，以进一步评估¹⁰ B 化合物作为 HCC 多学科治疗的效果。

更新日期：2020-05-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11