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Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma.
Applied Radiation and Isotopes ( IF 1.6 ) Pub Date : 2020-05-13 , DOI: 10.1016/j.apradiso.2020.109202
Hironobu Yanagie 1 , Masashi Yanagawa 2 , Tsuyoshi Higuchi 3 , Ryouji Mizumachi 3 , Mitsuteru Fujihara 4 , Yasuyuki Morishita 5 , Yuriko Sakurai 6 , Kikue Mouri 6 , Novriana Dewi 6 , Yasumasa Nonaka 7 , Atsuko Shinohara 8 , Takehisa Matsukawa 9 , Ayano Kubota 9 , Kazuhito Yokoyama 9 , Minoru Suzuki 10 , Shin-Ichiro Masunaga 10 , Yohinori Sakurai 10 , Hiroki Tanaka 10 , Koji Ono 11 , Haruo Yamauchi 12 , Minoru Ono 12 , Jun Nakajima 13 , Shushi Higashi 14 , Hiroyuki Takahashi 15
Affiliation  

We developed a mixing medical device by attaching Shirasu porous glass Millipore membrane to prepare water-in-oil-in-water (WOW) emulsion in a shorter time to be applied as 10B-entrapped WOW emulsion for hepatocellular carcinoma (HCC) treatment. Single-dose toxicity studies by intra-arterial injection of 10BSH-entrapped WOW were performed in rabbits and pig, and no side effects were observed. We hope to proceed to the preclinical and clinical studies for further evaluation of 10B compound as multidisciplinary treatments for HCC.



中文翻译:

通过动脉内注射 10BSH 包埋的水包油包水乳剂进行硼中子俘获治疗肝细胞癌的单剂量毒性研究。

我们开发了一种混合医疗设备,通过附着 Shirasu 多孔玻璃 Millipore 膜,在更短的时间内制备水包油包水 (WOW) 乳液,作为包埋10 B 的 WOW 乳液应用于肝细胞癌 (HCC) 治疗。在兔和猪中通过动脉内注射10 个BSH 包裹的 WOW 进行了单剂量毒性研究,没有观察到副作用。我们希望继续进行临床前和临床研究,以进一步评估10 B 化合物作为 HCC 多学科治疗的效果。

更新日期:2020-05-13
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