One of the eligible criteria for patients to receive boron neutron capture therapy (BNCT) is based on the tumour-to-normal ratio (T/N) measured by FBPA-PET. However, there is no standard protocol for normal region-of-interested delineation. With comparison of contralateral cerebrum, our study revealed the consistency (p < 0.05) and high feasibility using the cerebellum as an alternative normal tissue baseline because of its homogeneous uptake. Following RECIST version 1.1, the standard-operating-procedure (SOP) for the BNCT fulfilled the expected tumour response and tumour shrinkage rate (p < 0.05). Our modified procedure can provide more precise information for BNCT within a reasonable time.

患者接受硼中子俘获疗法 (BNCT) 的合格标准之一是基于 FBPA-PET 测量的肿瘤与正常比率 (T/N)。但是，没有用于正常感兴趣区域划定的标准协议。通过与对侧大脑的比较，我们的研究揭示了 使用小脑作为替代正常组织基线的一致性（p < 0.05）和高可行性，因为它的吸收均匀。在 RECIST 1.1 版之后，BNCT 的标准操作程序 (SOP) 满足了预期的肿瘤反应和肿瘤缩小率 ( p  < 0.05)。我们修改后的程序可以在合理的时间内为 BNCT 提供更精确的信息。