A 23 year old lady presented with sudden onset quadriparesis and examination revealed internuclear ophthalmoplegia with quadriparesis. MR Imaging revealed infarct in the midbrain with microhemorrhages. She also had asymmetrical weakness of ankles which was more on the right side for 1 ½ years. Nerve conduction study revealed sensorimotor axonal polyneuropathy and sural nerve biopsy was suggestive of vasculitis. Workup revealed anti beta-2 glycoprotein antibody positivity on 2 occasions 12 weeks apart with negative ANA, ANCA, VDRL and anticardiolipin antibodies. She was started on aspirin for secondary stroke prophylaxis and mycophenolate mofetil for management of the vasculitis. She improved with no further deficits and is doing fine at 3 years of follow up.

一名23岁的女士突然发作四肢瘫痪并进行检查，发现核内眼肌麻痹并伴有四肢瘫痪。MR成像显示中脑梗塞伴有微出血。她还患有踝关节不对称的无力，这种情况多出现在右侧1.5年。神经传导研究显示感觉运动性轴索性多神经病和腓肠神经活检提示血管炎。后检查显示，与ANA，ANCA，VDRL和抗心磷脂抗体阴性的抗体相隔12周有2次抗β-2糖蛋白抗体阳性。她开始使用阿司匹林预防继发性中风，并开始使用霉酚酸酯治疗血管炎。她的病情得到了改善，没有任何进一步的缺陷，并且在随访3年中表现良好。