As a severe and highly contagious infectious disease, coronavirus disease 2019 (COVID-19) has caused a global pandemic. Several case reports have demonstrated that the respiratory system is the main target in patients with COVID-19, but the disease is not limited to the respiratory system. Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. Importantly, the involvement of the CNS may be associated with poor prognosis and disease worsening. Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients.

中文翻译：

---

SARS-CoV-2 感染中神经系统的参与。

2019 冠状病毒病（COVID-19）作为一种严重的高传染性传染病，已在全球范围内引起大流行。几份病例报告表明，呼吸系统是 COVID-19 患者的主要靶点，但疾病并不局限于呼吸系统。病例分析表明，严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）可侵犯神经系统，36.4%的COVID-19患者有神经系统症状。重要的是，中枢神经系统的受累可能与预后不良和疾病恶化有关。在这里，我们讨论了 SARS-CoV-2 感染引起的神经系统受累（直接和间接）的症状和证据以及可能的机制。CNS 症状可能是预后不良的潜在指标；所以，