A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration,Materials Chemistry Frontiers

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A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2020-05-13 , DOI: 10.1039/d0qm00125b
Yingchun Su _{1,

2,

3,

4,

5} , Mehmet Berat Taskin _{6,

7,

8,

9} , Mingdong Dong _{6,

7,

8,

9} , Xiaojun Han _{1,

2,

3,

4,

5} , Flemming Besenbacher _{6,

7,

8,

9} , Menglin Chen _{6,

7,

8,

9,

10}

Affiliation

A helical perversion as a singularity structure is widely seen in nature, such as a climbing plant tendril, which is referred to as a kinked state connecting two helices with opposite chirality. Although previous macroscale elastic bistrip systems have been used to fabricate multiple helix-perversion structures, it is still challenging to obtain multi-perversions on the microscale. Herein, we have for the first time, discovered an interesting phenomenon when PCL microcoils were assembled on PEO/PCL microstems using wet, side-by-side electrospinning which combines side-by-side electrospinning with coagulation bath collection. Such side-by-side electrospun Janus microfibers, due to the mismatch strain between the two jets in the coagulation bath, are transformed into 3D multi-helix-perversion microstructures through self-scrolling. On the 3D multi-helix-perversion microstructures, the growth of HUVECs (human umbilical vein endothelial cells) are observed with a preferential cell distribution of around 86% on the PCL microcoils. Simultaneously, higher focal adhesion, enhanced cell proliferation and elongation are also exhibited by the PCL microcoils, leading to a distinctive 3D Janus cellular pattern. Such novel 3D multi-helix-perversion microstructures have great potential in 3D Janus biomaterials for adjustable cell patterning.

中文翻译：

具有自发3D Janus多螺旋变态配置的生物相容性人工卷须

螺旋形变态作为奇异性结构在自然界中很常见，例如攀爬植物的卷须，这被称为将两个具有相反手性的螺旋连接起来的扭结状态。尽管先前的宏尺度弹性双条带系统已用于制造多个螺旋形变结构，但在微尺度上获得多个变形仍然具有挑战性。在本文中，我们首次发现了一种有趣的现象，即使用湿式并排静电纺丝（将并排静电纺丝与凝结浴收集相结合）将PCL微线圈组装到PEO / PCL微型阀杆上。由于凝结浴中两个喷嘴之间的失配应变，这种并排的静电纺Janus超细纤维会通过自滚动转变为3D多螺旋形变微结构。在3D多螺旋变态微结构上，观察到HUVEC（人脐静脉内皮细胞）的生长，PCL微线圈上的优先细胞分布约为86％。同时，PCL微线圈还表现出更高的粘着力，增强的细胞增殖能力和伸长率，从而形成独特的3D Janus细胞模式。这种新颖的3D多螺旋变形微结构在3D Janus生物材料中具有可调节细胞图案的巨大潜力。形成独特的3D Janus细胞图案。这种新颖的3D多螺旋变形微结构在3D Janus生物材料中具有可调节细胞图案的巨大潜力。形成独特的3D Janus细胞图案。这种新颖的3D多螺旋变形微结构在3D Janus生物材料中具有可调节细胞图案的巨大潜力。

更新日期：2020-07-02

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