Subthalamic deep brain stimulation for Parkinson's disease may not ameliorate burden among caregivers. An 8-session, manualized program of cognitive-behavioral therapy (CBT) was delivered to a pilot sample of 10 caregivers (6 females, mean age: 60, age range: 34-79). Primary outcome measures were caregiver burden (Zarit Burden Interview) and caregiver quality of life (Parkinson's Disease Questionnaire-Carer). Secondary outcome measures comprised ratings of depression and anxiety in the caregiver, in addition to relationship quality. Caregiver burden (t = 2.91 P = .017) and caregiver anxiety (t = 2.82 P = .020) symptoms were significantly reduced at completion of the program, and these benefits were maintained 3 months later. Caregiver quality of life had significantly improved by the end of the intervention (t = 3.02 P = .015), but this effect was not sustained after 3 months. The longitudinal influence of participation in the program on caregiver burden was confirmed in a linear, mixed-effects model, χ2 (3) = 15.1, P = .0017). The intervention was well received by participants, and qualitative feedback was obtained. These results indicate that caregiver burden is modifiable in this cohort with a short course of CBT, that benefits are maintained after termination of the program, and that psychological treatment is acceptable to participants. Larger, controlled trials are justified.

中文翻译：

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对帕金森病患者进行脑深部刺激后的护理人员认知行为疗法的试点试验。

针对帕金森病的丘脑深部脑刺激可能不会减轻护理人员的负担。一个 8 个疗程的手动认知行为疗法 (CBT) 计划被提供给 10 名护理人员（6 名女性，平均年龄：60，年龄范围：34-79 岁）的试点样本。主要结局指标是看护者负担（Zarit Burden 访谈）和看护者生活质量（帕金森病问卷 - 看护者）。次要结果指标包括照顾者的抑郁和焦虑评分，以及关系质量。护理人员负担 (t = 2.91 P = .017) 和护理人员焦虑 (t = 2.82 P = .020) 症状在项目完成后显着减轻，并且这些益处在 3 个月后得以维持。干预结束时，看护者的生活质量显着提高（t = 3.02 P = .015），但这种效果在 3 个月后并未持续。参与该计划对照顾者负担的纵向影响在线性混合效应模型中得到证实，χ2 (3) = 15.1，P = .0017。干预得到了参与者的好评，并获得了定性反馈。这些结果表明，在该队列中，通过短期 CBT 治疗，看护者的负担是可以改变的，在计划终止后仍能保持受益，并且参与者可以接受心理治疗。更大规模的对照试验是合理的。这些结果表明，在该队列中，通过短期 CBT 治疗，看护者的负担是可以改变的，在计划终止后仍能保持受益，并且参与者可以接受心理治疗。更大规模的对照试验是合理的。这些结果表明，在这个队列中，通过短期 CBT 治疗，看护者的负担是可以改变的，在计划终止后福利仍然存在，并且参与者可以接受心理治疗。更大规模的对照试验是合理的。