OBJECTIVE Determine if femoral chondral cartilage degeneration on cadaveric knee joints exacerbate differently with aging between the sexes. METHODS A total of 85 cadaveric femurs were assessed for macroscopic femoral condyle pathology using a scale for gross signs of osteoarthritis. Raters scored specimens and raters' scores were averaged to provide each specimen a Disease Severity Score (DSS). RESULTS The DSS for the 80+-year-old population was greater than the DSS of the 70- to 79-year-old population (*P < 0.05) and the <70-year-old population (**P < 0.01). Specimens that scored a DSS of 2 and higher were assessed for their specific site of most severe degeneration. The most severe degeneration on the articular cartilage was most regularly on the patellar fossa. The second most degenerated region varied by age and biomechanical alterations. There were no significant changes in DSS between the sexes within the age groups. CONCLUSIONS No difference was shown between the sexes in the severity or location of degeneration indicating that men and women are likely affected by the same biomechanical changes that spur on osteoarthritis in their eighth decade of life (70s) and later. Lateral femoral degeneration predominates in younger populations. When patients approach their 70s, medial degeneration begins to predominate likely based on an increase in shearing at the knee joint.

中文翻译：

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老年男性和女性股骨髁骨关节炎程度的评估：尸体研究。


目的 确定尸体膝关节股骨软骨退化的恶化情况是否随性别年龄的增长而不同。方法 使用骨关节炎总体体征量表对总共 85 具尸体股骨进行宏观股骨髁病理学评估。评估者对样本进行评分，并对评估者的分数进行平均，为每个样本提供疾病严重程度评分 (DSS)。结果 80 岁以上人口的 DSS 大于 70 至 79 岁人口的 DSS (*P < 0.05) 和 <70 岁人口的 DSS (**P < 0.01）。对 DSS 得分为 2 或更高的样本进行最严重退化的特定部位评估。关节软骨最严重的退化最常见于髌骨窝。第二个退化最严重的区域因年龄和生物力学变化而异。各年龄组内不同性别之间的 DSS 没有显着变化。结论 性别之间在退化的严重程度或位置上没有显示出差异，这表明男性和女性可能会受到相同的生物力学变化的影响，这些变化会在八十几岁（70多岁）及以后引发骨关节炎。股骨外侧退变在年轻人群中占主导地位。当患者接近 70 岁时，由于膝关节剪切力的增加，内侧变性可能开始占主导地位。