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A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967.
Microbiology and Molecular Biology Reviews ( IF 12.9 ) Pub Date : 2020-05-13 , DOI: 10.1128/mmbr.00095-19
Elizabeta S Ristanović 1 , Nenad S Kokoškov 2 , Ian Crozier 3 , Jens H Kuhn 4 , Ana S Gligić 5
Affiliation  

SUMMARYIn 1967, several workers involved in poliomyelitis vaccine development and production fell ill at three different locations in Europe with a severe and often lethal novel disease associated with grivets (Chlorocebus aethiops) imported from Uganda. This disease was named Marburg virus disease (MVD) after the West German town of Marburg an der Lahn, where most human infections and deaths had been recorded. Consequently, the Marburg episode received the most scientific and media attention. Cases that occurred in Frankfurt am Main, West Germany, were also described in commonly accessible scientific literature, although they were less frequently cited than those pertaining to the Marburg infections. However, two infections occurring in a third location, in Belgrade, Yugoslavia, have seemingly been all but forgotten. Due in part to their absence in commonly used databases and in part to the fact that they were written in languages other than English, the important articles describing this part of the outbreak are very rarely cited. Here, we summarize this literature and correct published inaccuracies to remind a younger generation of scientists focusing on Marburg virus and its closest filoviral relatives of this important historical context. Importantly, and unfortunately, the three episodes of infection of 1967 still represent the best in-depth clinical look at MVD in general and in the context of "modern" medicine (fully resourced versus less-resourced capacity) in particular. Hence, each individual case of these episodes holds crucial information for health care providers who may be confronted with MVD today.

中文翻译:

马尔堡病毒病的遗忘集:1967年,南斯拉夫贝尔格莱德。

总结1967年,几名从事脊髓灰质炎疫苗开发和生产的工人在欧洲三个不同的地方生病,患上了从乌干达进口的gr虫(Chlorocebus aethiops)相关的严重且通常是致命的新型疾病。该疾病以西德小镇马尔堡河畔安德堡(Marburg an der Lahn)命名为马尔堡病毒病(MVD),那里记录了大多数人类感染和死亡的情况。因此,马尔堡事件引起了最科学和媒体的关注。虽然文献引用率不如涉及马尔堡感染的病例,但经常引用的科学文献中也描述了在西德美因河畔法兰克福发生的病例。但是,在南斯拉夫贝尔格莱德的第三处发生的两次感染似乎几乎被遗忘了。部分原因是由于它们在常用数据库中不存在,部分原因是它们用英语以外的其他语言编写,因此很少引用描述爆发这一部分的重要文章。在这里,我们总结了这些文献并纠正了所发表的错误之处,以提醒关注这一重要历史背景的年轻一代专注于马尔堡病毒及其最亲近亲属的科学家。重要的是,不幸的是,1967年的三例感染仍然代表了对MVD最好的深入临床观察,尤其是在“现代”医学(资源充足而资源较少的情况下)的情况下。因此,这些事件的每一个个案都为当今可能面临MVD的医疗保健提供者提供了至关重要的信息。
更新日期:2020-05-13
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