The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki–Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki–Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.

中文翻译：

---

铃木-宫浦交叉偶联并不是展示新溶剂性能的信息丰富的反应。


由于防止或限制许多传统溶剂使用的法规激增，新溶剂的开发和研究变得非常重要。在这项工作中，评估了铃木-宫浦反应证明新溶剂的适用性，包括 Cyrene™、二甲基异山梨醇、乳酸乙酯、2-甲基四氢呋喃 (2-MeTHF)、碳酸丙烯酯和 γ-戊内酯 (GVL) ）。研究发现，交叉偶联通常不受溶剂选择的影响，因此铃木-宫浦反应提供的关于任何特定溶剂在有机合成中的有用性的信息有限。