ABSTRACT

Background: Rehabilitation in cerebral palsy (CP) seeks to harness neuroplasticity to improve movement, including walking, yet cortical activation underlying gait is not well understood.

Methods: We used electroencephalography (EEG) to compare motor related cortical activity, measured by mu rhythm, during quiet standing and treadmill walking in 10 children with unilateral CP and 10 age- and sex-matched children with typical development (TD). Peak mu band frequency, mu rhythm desynchronization (MRD), and gait related intra- and inter-hemispheric coherence were examined.

Results: MRD during walking was observed bilaterally over motor cortex in both cohorts but peak mu band frequency showing MRD was significantly lower in CP compared to TD. Coherence during quiet standing between motor and frontal regions was significantly higher in the non-dominant compared to dominant hemisphere in CP with no hemispheric differences in TD.

Conclusions: EEG-based measures should be further investigated as clinical biomarkers for atypical motor development and to assess rehabilitation effectiveness.

摘要

背景：脑瘫 (CP) 康复试图利用神经可塑性来改善运动，包括行走，但步态下的皮质激活尚不清楚。

方法：我们使用脑电图 (EEG) 来比较 10 名单侧 CP 儿童和 10 名年龄和性别匹配的典型发育 (TD) 儿童在安静站立和跑步机行走期间通过 mu 节律测量的运动相关皮层活动。检查了峰值 mu 频带频率、mu 节奏去同步化 (MRD) 和步态相关的半球内和间相干性。

结果：行走期间的 MRD 在两个队列的双侧运动皮层上均被观察到，但与 TD 相比，显示 MRD 的峰值 mu 波段频率在 CP 中显着较低。与 CP 中的优势半球相比，在 CP 中非优势半球的运动和额叶区域之间安静站立期间的一致性明显更高，而 TD 中没有半球差异。

结论：应进一步研究基于脑电图的措施作为非典型运动发育的临床生物标志物并评估康复效果。