The aim of this study was to determine the rate and types of lifetime psychiatric disorders, as well as their predictors, in a sample of people with refractory epilepsy. Demographic, neurological, psychiatric and neuropsychological data, from people with refractory epilepsy, were registered at the pre-surgical interview. Linear regression was used to determine predictors. One hundred and ninety-one participants were included. Forty-six percent of our sample had at least one previous psychiatric diagnosis, most frequently depressive (64%), anxiety (10%), substance use (10%) and psychotic disorders (6%). Patients with a right-side epileptogenic zone had an increased risk for these disorders (OR 2.36; CI 1.22–4.56; p = 0.01). Specific epilepsy-related factors may raise the risk of developing a psychiatric disorder. Our study adds evidence to support a bidirectional relationship between epilepsy and mental health.

这项研究的目的是确定难治性癫痫患者样本中终生精神疾病的发生率和类型及其预测因素。在手术前访谈中记录了难治性癫痫患者的人口统计学，神经病学，精神病学和神经心理学数据。线性回归用于确定预测变量。包括191名参与者。我们的样本中有46％至少有过一次精神病诊断，最常见的是抑郁（64％），焦虑（10％），药物滥用（10％）和精神病（6％）。右侧癫痫源区的患者发生这些疾病的风险增加（OR 2.36； CI 1.22-4.56；p = 0.01）。特定的癫痫相关因素可能会增加患精神病的风险。我们的研究增加了证据支持癫痫与心理健康之间的双向关系。