The nanoemulsion system can improve stability to antioxidant molecules when compared to the isolated molecule. Therefore, this study aimed to establish conditions on thermal stability, chemical characterization, antioxidant and anti-inflammatory activity of lycopene nanoemulsion. Different chemical assays were used to characterize the lycopene nanoemulsion (LN) and the purified lycopene from guava (LPG) as HPLC, UV-Vis, DLS, and ABTS to analyze the antioxidant activity of lycopene nanoemulsion. To test its thermal stability as an antioxidant in nanoemulsion it was used the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) techniques. The carrageenan-induced paw edema model in Swiss mice and histopathological analysis were used to evaluate anti-inflammatory activity. Emulsion with a mean droplet size of z-Average diameter 167.1 d.nm was produced. UV-vis detected λ_max = 447.1, 473.7, and 505.3 nm to lycopene from guava and HPLC-DAD analysis by C₃₀ at 472 nm identified the presence of lycopene in the nanoemulsion. This lycopene nanoemulsion presented thermal stability at room temperature, as well as on concentration when stored for one year. Also significantly inhibited (p < 0.05) the edema formation, with maximum inhibitory effect at 50 mg/kg by oral and intraperitoneal route and reduced neutrophil migration in paw tissue. The lycopene nanoemulsion can be a potential candidate for investigation and therapy of various diseases, including inflammation because this lycopene nanoemulsion presented therapeutics application for inflammatory diseases, and has also potential to be used as ointment and/or cream additive for topic applications.

与分离的分子相比，纳米乳液系统可以提高对抗氧化剂分子的稳定性。因此，本研究旨在建立番茄红素纳米乳液的热稳定性，化学表征，抗氧化剂和抗炎活性的条件。通过HPLC，UV-Vis，DLS和ABTS对番茄红素纳米乳液（LN）和番石榴提纯的番茄红素（LPG）进行了不同的化学分析，以分析番茄红素纳米乳液的抗氧化活性。为了测试其在纳米乳液中作为抗氧化剂的热稳定性，使用了热重分析（TGA）和差示扫描量热法（DSC）技术。角叉菜胶诱发的爪水肿模型在瑞士小鼠和组织病理学分析用于评估抗炎活性。制备具有平均液滴尺寸为z-平均直径167.1d.nm的乳液。番石榴中的番茄红素经UV-vis检测到_λmax = 447.1、473.7和505.3 nm，C ₃₀在472 nm处进行的HPLC-DAD分析确定了纳米乳液中番茄红素的存在。该番茄红素纳米乳液在室温下以及储存一年时的浓度下均表现出热稳定性。也显着抑制（p <0.05）水肿形成，通过口服和腹膜内途径最大抑制作用为50 mg / kg，并减少了爪组织中的中性粒细胞迁移。番茄红素纳米乳剂可以是研究和治疗包括炎症在内的各种疾病的潜在候选者，因为该番茄红素纳米乳剂在炎症性疾病中具有治疗应用，并且还具有用作主题应用的软膏和/或乳膏添加剂的潜力。