Background: Some studies have suggested that the insertion(I)/deletion(D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene may be associated with human longevity, especially in centenarians. However, this association is still controversial. Besides, there have been no studies in Peruvians.

Aim: To describe the age distribution of the ACE polymorphism in a convenience sample of Peruvian older people.

Subjects and methods: This was a cross-sectional study in 104 Geriatric Day Hospital patients in Lima, Perú. The ACE polymorphism was determined in all patients. For the purpose of association with age, the sample was divided into four categories: young (< 65), youngest-old (65–74), middle-old (75–84) and oldest-old (85 or more).

Results: The distribution of genotype frequencies was consistent with a population in Hardy-Weinberg equilibrium (p = 0.62). The number (%) of D/D, I/D and I/I genotypes in the young was 2 (14.3%), 3 (21.4%) and 9 (64.3%), respectively; in youngest-old: 4 (11.4%), 15 (42.9%) and 16 (45.7%); in middle-old: 6 (12.2%), 20 (40.8%) and 23 (46.9%); and in oldest-old: 0 (0.0%), 4 (66.7%) and 2 (33.3%). A chi-square analysis showed no significant differences in genotype distribution between age groups (p = 0.647).

Conclusion: No significant age differences were found in the distribution of the ACE polymorphism in this sample. Further studies with greater statistical power are recommended.

背景：一些研究表明，血管紧张素转换酶（ACE）基因的插入（I）/缺失（D）多态性可能与人类寿命有关，特别是在百岁老人中。但是，这种关联仍然存在争议。此外，秘鲁人还没有研究。

目的：描述秘鲁老年人便利样本中ACE多态性的年龄分布。

受试者和方法：这是一项对横穿秘鲁利马的104名老年日间医院患者的横断面研究。在所有患者中确定了ACE多态性。为了与年龄相关联，将样本分为四类：年轻人（<65岁），年轻人（65-74岁），中年（75-84岁）和年龄最大（85岁或以上）。

结果：基因型频率的分布与哈迪-温伯格平衡中的种群一致（p  = 0.62）。年轻人中D / D，I / D和I / I基因型的数量（％）分别为2（14.3％），3（21.4％）和9（64.3％）；最年轻的年龄段：4（11.4％），15（42.9％）和16（45.7％）；中年人：6（12.2％），20（40.8％）和23（46.9％）；年龄最大的人：0（0.0％），4（66.7％）和2（33.3％）。卡方分析显示不同年龄组之间的基因型分布无显着差异（p  = 0.647）。

结论：该样本中ACE多态性分布没有发现明显的年龄差异。建议进行具有更高统计功效的进一步研究。