Background: Body size in adult life is likely associated with risks of endometriosis and adenomyosis, yet little is known about associations with body size earlier in life.Aim: To examine whether birth weight, childhood body mass index (BMI) and height are associated with risks of endometriosis and adenomyosis.Subjects and methods: From the Copenhagen School Health Records Register, 171,447 girls born 1930-1996, with measured weights and heights at ages 7-13 were included. Outcomes were obtained from health registers. Cox regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI).Results: During follow-up, 2149 endometriosis cases and 1410 adenomyosis cases were diagnosed. Childhood BMI was inversely associated with endometriosis (HR = 0.92 [95% CI: 0.88-0.96] per z-score at age 7). In contrast, childhood height was positively associated with endometriosis (HR = 1.09 [95% CI: 1.05-1.14] per z-score at age 7). Associations with childhood body size did not differ by endometriosis location. Childhood BMI and height had limited associations with adenomyosis. Birth weight was not associated with endometriosis or adenomyosis.Conclusion: Lean and tall girls are more often diagnosed with endometriosis, but not adenomyosis. These findings suggest that indicators of endometriosis risk are already apparent at early ages.

中文翻译：

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出生体重，儿童体重指数和身高以及子宫内膜异位和子宫腺肌症的风险。

背景：成年后的体重可能与子宫内膜异位症和子宫腺肌症的风险有关，但对生命早期与体重的关系知之甚少。目的：研究出生体重，儿童体重指数（BMI）和身高是否与受试者和方法：受试者和方法：根据哥本哈根学校健康记录登记册，包括171,447名1930年至1996年出生的女孩，测量的体重和身高在7-13岁之间。结果从健康登记册获得。结果：在随访期间，诊断出2149例子宫内膜异位病例和1410例子宫腺肌病病例，并进行了Cox回归以估计危险比（HR）和95％置信区间（CI）。儿童BMI与子宫内膜异位呈负相关（7岁时每z得分HR = 0.92 [95％CI：0.88-0.96]）。相反，儿童身高与子宫内膜异位呈正相关（7岁时每个z得分HR = 1.09 [95％CI：1.05-1.14]）。子宫内膜异位的位置与童年体型的关联没有差异。儿童BMI和身高与子宫腺肌病的关联有限。出生体重与子宫内膜异位或子宫腺肌病无关。结论：瘦高个子女孩经常被诊断出子宫内膜异位，但并非子宫腺肌病。这些发现表明，子宫内膜异位症风险的指标在早期就已经很明显。瘦长个女孩经常被诊断出子宫内膜异位，但并非子宫腺肌病。这些发现表明，子宫内膜异位症危险性的指标在早期就已经很明显。瘦长个女孩经常被诊断出子宫内膜异位，但并非子宫腺肌病。这些发现表明，子宫内膜异位症危险性的指标在早期就已经很明显。