Abstract

Study:

Membrane trafficking process is significant for the complex and precise regulatory of the nervous system. Rab11, as a small GTPase of the Rab superfamily, controls endocytic vesicular trafficking to the cell surface after sorting in recycling endosome (RE), coordinating with its receptors to maintain neurological function.

Materials and methods

This article reviewed the literature of Rab11 in nervous system.

Results

Rab11-positive vesicles targeted transport growth-related molecules, such as integrins, protrudin, tropomyosin receptor kinase (Trk) A/B receptor and AMPA receptor (AMPAR) to membrane surface to promote the regeneration capacity of axon and dendrites and maintain synaptic plasticity. In addition, many studies have shown that the expression of Rab11 is decreased in multiple neurodegenerative diseases, which is highly correlated with the process of production, transport and clearance of disease-related pathological proteins. And overexpression or increased activity of Rab11 can greatly improve the defect of membrane trafficking and slow down the disease process.

Conclusion

With increasing research efforts on Rab11-dependent membrane trafficking mechanisms, a potential target for nerve regeneration and neurodegenerative diseases will be provided.

中文翻译：

---

Rab11 介导的再循环内体在神经系统发育和神经退行性疾病中的作用

摘要

学习：

膜运输过程对于神经系统的复杂和精确调节具有重要意义。Rab11 作为 Rab 超家族的一个小 GTPase，在循环内体 (RE) 中分选后控制内吞囊泡运输到细胞表面，与其受体协调以维持神经功能。

材料和方法

本文综述了Rab11在神经系统中的文献。

结果

Rab11阳性囊泡将整合素、protrudin、原肌球蛋白受体激酶（Trk）A/B受体和AMPA受体（AMPAR）等生长相关分子靶向转运至膜表面，促进轴突和树突的再生能力，维持突触可塑性。此外，多项研究表明，Rab11在多种神经退行性疾病中表达降低，这与疾病相关病理蛋白的产生、转运和清除过程高度相关。而 Rab11 的过表达或活性增加可以大大改善膜运输的缺陷并减缓疾病进程。

结论

随着对依赖 Rab11 的膜运输机制的研究力度不断加大，将为神经再生和神经退行性疾病提供一个潜在的靶点。