Abstract

Objects

Cerebral vasospasm is an important event that occurs following subarachnoid hemorage which has significant mortality and morbidity. The goal in this study was to investigate the effect of pentoxifylline on vasospasm in an experimental subarachnoid hemorrhage model.

Methods

In this study, 20 male New Zeland White rabbits weighing 3000–3500 g were assigned randomly to four groups. Animals in group 1 served as controls. Animals in group two received only intravenous pentoxifylline injection 3 times in 12 h intervals. In group 3, SAH was induced and no injection was given. Animals in group 4 received intravenous pentoxifylline (6 mg/kg) injections 3 times at 12^th, 24^th and 36^th hours after subarachnoid hemorrhage induction. All animals were sacrificed and basilar arteries were removed at 48th hour. Basilar artery vessel diameters, wall thicknesses and luminal section areas were measured with Spot for Windows version 4.1. Statistical analysis was performed using ANOVA and Kruskall–Wallis tests.

Results

Mean basilar artery luminal section areas and luminal diameters in group 4 were significantly higher compared to group 3 (p < 0.05). Basilar artery wall thicknesses and were found to be higher in group 3 than in other groups and this was also statistically significant (p < 0.05).

Conclusion

Our study demonstrated that intravenous administration of pentoxifylline significantly decreases vasospasm after subarachnoid hemorrhage.

中文翻译：

---

己酮可可碱对实验性蛛网膜下腔出血后脑血管痉挛的影响

摘要

对象

脑血管痉挛是蛛网膜下腔出血后发生的重要事件，具有显着的死亡率和发病率。本研究的目的是在实验性蛛网膜下腔出血模型中研究己酮可可碱对血管痉挛的影响。

方法

在这项研究中，20 只体重 3000-3500 g 的雄性新西兰白兔被随机分配到四组。第1组的动物作为对照。第二组动物仅接受静脉注射己酮可可碱3次，间隔12小时。第3组诱导SAH，不注射。在第4组动物接受静脉内己酮可可碱（6毫克/公斤）注射于12 3次^日，24^日和36^日蛛网膜下腔出血诱导后小时。在第 48 小时处死所有动物并移除基底动脉。使用 Spot for Windows 4.1 版测量基底动脉血管直径、壁厚和管腔截面面积。使用方差分析和 Kruskall-Wallis 检验进行统计分析。

结果

与第 3 组相比，第4 组的平均基底动脉管腔截面面积和管腔直径显着更高（p  < 0.05）。基底动脉壁厚度和基底动脉壁厚度在第 3 组中高于其他组，这也具有统计学意义 ( p  < 0.05)。

结论

我们的研究表明，静脉注射己酮可可碱可显着减少蛛网膜下腔出血后的血管痉挛。