Abstract

Objective

The aim of this study was to explore the effects of atypical antipsychotics (AaPs) on brain white matter (WM) tracts in healthy individuals with auditory verbal hallucinations (Hi-AVHs).

Methods

We analyzed neuroimaging, AVH symptoms, and cognitive assessment data obtained from 39 Hi-AVHs who reported being distressed by persistent AVHs and volunteered to receive AaP treatment. We used tract-based spatial statistics (TBSS) and t tests to explore AaP pharmacotherapy effects on AVH symptoms and brain WM alterations in Hi-AVH subjects.

Results

TBSS and t tests revealed WM alterations after AaP treatment, relative to pretreatment observations. Although AaPs alleviated AVH symptoms, WM alterations in these subjects expanded over 8 months of AaP treatment, encompassing most major WM tracts by the end of the observation period, including the corpus callosum, arcuate fasciculus, cortico-spinal tracts, anterior commissure, and posterior commissure.

Conclusions

The worsening of AaP-associated WM alterations observed in this study suggest that AaPs may not be a good choice for the treatment of Hi-AVHs despite their ability to alleviate AVHs.

中文翻译：

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一种典型的抗精神病药物疗法可诱导健康的个体不断出现听觉幻觉，从而逐渐扩大其白质变化，这是一项人工控制的先导研究

摘要

客观的

这项研究的目的是探讨非典型抗精神病药（AaPs）对具有听觉言语幻觉（Hi-AVHs）的健康个体的脑白质（WM）道的影响。

方法

我们分析了从39例Hi-AVH中获得的神经影像学，AVH症状和认知评估数据，这些人报告称其受到持续性AVH困扰并自愿接受AaP治疗。我们使用基于道的空间统计（TBSS）和t检验来探讨AaP药物治疗对高AVH受试者AVH症状和脑WM改变的影响。

结果

TBSS和t检验显示，相对于治疗前的观察结果，AaP治疗后WM改变。尽管AaP缓解了AVH症状，但这些受试者的WM改变在AaP治疗的8个月内有所扩大，包括观察期末大部分的主要WM道，包括call体，弓形束，皮质脊髓道，前连合和后路。合身。

结论

在这项研究中观察到的与AaP相关的WM改变的恶化表明，尽管AaP能够缓解AVH，但可能不是治疗Hi-AVH的好选择。