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A typical antipsychotic treatment induced gradually expanding white matter alterations in healthy individuals with persistent auditory verbal hallucinations—an artificially controlled pilot study
International Journal of Neuroscience ( IF 1.7 ) Pub Date : 2020-04-30 , DOI: 10.1080/00207454.2020.1750387
Xiaodong Lin 1 , Gongying Li 2 , Feng Ji 2 , Langlang Cheng 1 , Guangdong Chen 1 , Wei Zhang 1 , Zhonghua Su 2 , Zhenqing Zhang 3 , Wenqiang Wang 3 , Chunhua Zhou 4 , Yong Xu 5 , Chuanjun Zhuo 1, 2, 3, 6
Affiliation  

Abstract

Objective

The aim of this study was to explore the effects of atypical antipsychotics (AaPs) on brain white matter (WM) tracts in healthy individuals with auditory verbal hallucinations (Hi-AVHs).

Methods

We analyzed neuroimaging, AVH symptoms, and cognitive assessment data obtained from 39 Hi-AVHs who reported being distressed by persistent AVHs and volunteered to receive AaP treatment. We used tract-based spatial statistics (TBSS) and t tests to explore AaP pharmacotherapy effects on AVH symptoms and brain WM alterations in Hi-AVH subjects.

Results

TBSS and t tests revealed WM alterations after AaP treatment, relative to pretreatment observations. Although AaPs alleviated AVH symptoms, WM alterations in these subjects expanded over 8 months of AaP treatment, encompassing most major WM tracts by the end of the observation period, including the corpus callosum, arcuate fasciculus, cortico-spinal tracts, anterior commissure, and posterior commissure.

Conclusions

The worsening of AaP-associated WM alterations observed in this study suggest that AaPs may not be a good choice for the treatment of Hi-AVHs despite their ability to alleviate AVHs.



中文翻译:

一种典型的抗精神病药物疗法可诱导健康的个体不断出现听觉幻觉,从而逐渐扩大其白质变化,这是一项人工控制的先导研究

摘要

客观的

这项研究的目的是探讨非典型抗精神病药(AaPs)对具有听觉言语幻觉(Hi-AVHs)的健康个体的脑白质(WM)道的影响。

方法

我们分析了从39例Hi-AVH中获得的神经影像学,AVH症状和认知评估数据,这些人报告称其受到持续性AVH困扰并自愿接受AaP治疗。我们使用基于道的空间统计(TBSS)和t检验来探讨AaP药物治疗对高AVH受试者AVH症状和脑WM改变的影响。

结果

TBSS和t检验显示,相对于治疗前的观察结果,AaP治疗后WM改变。尽管AaP缓解了AVH症状,但这些受试者的WM改变在AaP治疗的8个月内有所扩大,包括观察期末大部分的主要WM道,包括call体,弓形束,皮质脊髓道,前连合和后路。合身。

结论

在这项研究中观察到的与AaP相关的WM改变的恶化表明,尽管AaP能够缓解AVH,但可能不是治疗Hi-AVH的好选择。

更新日期:2020-04-30
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