ABSTRACT The biosafety of ultra-wideband (UWB) pulses, which are characterized by simultaneously high power and a high bandwidth ratio, has gained increasing attention. Although there is substantial prior literature on the biological effects of UWB pulses on both cells and animals, an explicit, unequivocal and definite pattern of the corresponding biological responses remains elusive, and the systemic secondary consequences are also still not fully understood. In this study, we found that exposing mice to UWB pulses resulted in the alteration of several biochemical blood parameters, which further prompted us to investigate changes in the liver and kidneys of mice exposed to UWB pulses with different field intensities and different durations. The data demonstrated that exposure to UWB pulses significantly increased the levels of ALT and AST, increased oxidative stress, and could even induce the accumulation of lipid droplets in hepatocytes. The total number of pulses under the tested acute exposure regiment contributed most to the observed hepatic and rental dysfunction. Notably, the physiological and molecular changes recovered approximately 72 hours after exposure. These results imply the potential risk of acute exposure to UWB pulses, and highlight the meaningful targets for further long-term study of chronic exposure.

中文翻译：

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超宽带脉冲电磁场​​急性暴露对小鼠肝肾的影响

摘要 超宽带 (UWB) 脉冲具有同时具有高功率和高带宽比的特点，其生物安全性越来越受到关注。尽管有大量关于 UWB 脉冲对细胞和动物的生物学影响的先前文献，但相应生物学反应的明确、明确和确定的模式仍然难以捉摸，而且系统性次要后果也仍未完全了解。在这项研究中，我们发现将小鼠暴露于 UWB 脉冲会导致几种生化血液参数的改变，这进一步促使我们研究暴露于不同场强和不同持续时间的 UWB 脉冲的小鼠肝脏和肾脏的变化。数据表明，暴露于 UWB 脉冲显着增加了 ALT 和 AST 的水平，氧化应激增加，甚至可以诱导肝细胞中脂滴的积累。在测试的急性暴露组下的脉冲总数对观察到的肝脏和租赁功能障碍的贡献最大。值得注意的是，生理和分子变化在暴露后大约 72 小时恢复。这些结果暗示了急性暴露于超宽带脉冲的潜在风险，并突出了对慢性暴露进行进一步长期研究的有意义的目标。