ABSTRACT In this study, a correlation between cell channel α-helices displacement and the mitochondrial transmembrane potential after exposure of 3, 7, 15 and 24 h of neuronal-like cells to a uniform magnetic field at the intensity of 2 mT was shown. Fourier Transform Infrared (FTIR) Spectroscopy and fluorescence techniques were used to analyze the secondary structure of protein content and mitochondrial transmembrane potential, respectively. The main result of this study was represented by a significant inverse relation between the mitochondrial transmembrane potential and the intensity of the Amide I band that can be associated with time exposure. Given that mitochondrial transmembrane potential should be related to the gating state of voltage-dependent anion channel (VDAC) in mitochondrial membrane, this result could have a relevant role in medicine. Indeed, VDAC's irregular behavior can be associated with several varieties of mitochondria-associated pathologies and various forms of cancer and neurodegeneration.

中文翻译：

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静磁场作用下神经元样细胞线粒体跨膜电位与蛋白质α-螺旋的反比关系及VDAC的作用

摘要 在这项研究中，显示了将神经元样细胞暴露于 2 mT 强度的均匀磁场 3、7、15 和 24 小时后，细胞通道 α-螺旋位移与线粒体跨膜电位之间的相关性。傅里叶变换红外 (FTIR) 光谱和荧光技术分别用于分析蛋白质含量和线粒体跨膜电位的二级结构。这项研究的主要结果是线粒体跨膜电位与酰胺 I 带强度之间的显着负相关，这与时间暴露有关。鉴于线粒体跨膜电位应与线粒体膜电压依赖性阴离子通道（VDAC）的门控状态有关，这一结果可能在医学中发挥相关作用。事实上，VDAC 的不规则行为可能与多种线粒体相关病理以及各种形式的癌症和神经变性有关。