ABSTRACT Active research is invested in early diagnosis of malignant cells in order to allow scope for effective treatment. The electrical impedance measurements and the modeling techniques used to perform the calculation for dielectric permittivity, conductivity and relaxation frequency aids in the differentiation of malignant and healthy cells. The literature showed a general trend in data with malignant cells having higher electrical conductivity and lower dielectric permittivity than its surrounding healthier cells. However, the relaxation frequency that correlates with the dielectric loss factor was found twice in magnitude for cancer cells than healthy cells. The water content of a cancer cell is found higher and hence correlates with the shift in the relaxation time. The intracellular sodium ion concentration is also realized to be higher for malignant cells than normal cells and accounts for the depolarized transmembrane potential. Hence, this paper forms the framework for future technological innovation that can be taken into account to actively diagnose cancer cell.

中文翻译：

---

积极分化恶性和正常细胞的生物介电现象：概述

摘要 积极的研究投资于恶性细胞的早期诊断，以便为有效治疗留出空间。用于执行介电常数、电导率和弛豫频率计算的电阻抗测量和建模技术有助于区分恶性细胞和健康细胞。文献显示恶性细胞比其周围的健康细胞具有更高的电导率和更低的介电常数的数据的总体趋势。然而，发现与介电损耗因子相关的弛豫频率对于癌细胞来说是健康细胞的两倍。发现癌细胞的水含量更高，因此与弛豫时间的变化相关。恶性细胞的细胞内钠离子浓度也被认为高于正常细胞，并解释了去极化的跨膜电位。因此，本文形成了未来技术创新的框架，可以考虑到积极诊断癌细胞。