Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. This study aimed to evaluate the relationship between polyploidy, centrosome abnormalities, and response to endocrine treatment in progestin-induced mouse mammary carcinomas. We found cells with three or more centrosomes in the polyploid tumors. The endocrine unresponsive tumors showed a higher average number of centrosomes per cell than the responsive tumors. The results suggest an association between polyploidy and centrosome amplification with the resistance to endocrine therapy in this luminal breast cancer model.

中文翻译：

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荷尔蒙反应不同程度的小鼠乳腺癌中心体异常和多倍体。

中心体扩增导致异常的有丝分裂，引起非整倍性，并且与人类癌症的不良预后有关。这项研究旨在评估孕激素诱导的小鼠乳腺癌多倍体，中心体异常与内分泌治疗反应之间的关系。我们在多倍体肿瘤中发现了具有三个或更多中心体的细胞。内分泌无反应性肿瘤比反应性肿瘤显示出更高的平均每个细胞中心体数量。结果表明，在这种管腔型乳腺癌模型中，多倍体和中心体扩增与对内分泌治疗的抗性有关。