ABSTRACT Here we present the synthesis of complementary (pseudo) nucleobase appended Supramolecular Self-associating Amphiphilic (SSA) salts and, establish the potential for this molecular construct to produce a new class of DNA inspired synthetic structures/materials. The anionic component of this class of amphiphile contains multiple hydrogen bond donating and accepting functionalities, meaning that these systems can access multiple self-associative hydrogen-bonding modes simultaneously. Herein, we characterise the self-associative properties of these DNA inspired amphiphiles in the solid state, solution state and gas phase. Finally, we investigate the potential of these amphiphilic salts to act as antimicrobial agents against model Gram-positive (methicillin-resistant Staphylococcus aureus – MRSA) and Gram-negative (Escherichia coli – E. coli) bacteria. Graphical Abstract

中文翻译：

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使用（伪）核碱基取代的两亲物作为 DNA 核苷酸模拟物和抗菌剂

摘要在这里，我们介绍了附加的互补（伪）核碱基附加超分子自缔合两亲 (SSA) 盐的合成，并建立了这种分子构建体产生一类新的 DNA 启发合成结构/材料的潜力。这类两亲物的阴离子组分包含多个氢键供体和接受功能，这意味着这些系统可以同时访问多个自缔合氢键模式。在此，我们表征了这些受 DNA 启发的两亲物在固态、溶液态和气相中的自缔合特性。最后，我们研究了这些两亲盐作为抗革兰氏阳性模型（耐甲氧西林金黄色葡萄球菌 – MRSA）和革兰氏阴性模型（大肠杆菌 – 大肠杆菌）的抗菌剂的潜力。大肠杆菌）细菌。图形概要