ABSTRACT Substituted oligoamides are short sequences of unnatural amino acids. Oligoamides made entirely of β3 amino acids yield helical monomers that, if N-acylated, assemble into nanorod structures via a supramolecular assembly motif. In this work, coordination crosslinking was used to create complex nanomaterials from oligoamides WKLWEL (KE) and WELWEL (EE) (the letters denote the analogous α-amino acids). Upon Cu(II) addition, atomic force microscopy and small angle neutron scattering revealed morphologic changes specific to KE but absent in EE. Vibration spectroscopy measurements revealed that Cu(II) can coordinate to the amine moieties of the side chains, without direct effect on the backbone amides. While coordination in excess solvent lead to regular nanostructures, fast drying of the sample yielded oligoamide templated crystallization of CuCl2. The metal coordination crosslinking of supramolecular assemblies as reported here is the first realization of a metallosupramolecular framework structure. Graphical Abstract

中文翻译：

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螺旋取代的低聚酰胺纳米棒与 Cu(II) 的配位交联

摘要 取代寡酰胺是非天然氨基酸的短序列。完全由 β3 氨基酸组成的低聚酰胺产生螺旋单体，如果 N 酰化，则通过超分子组装基序组装成纳米棒结构。在这项工作中，配位交联用于从低聚酰胺 WKLWEL (KE) 和 WELWEL (EE)（字母表示类似的 α-氨基酸）制造复杂的纳米材料。添加 Cu(II) 后，原子力显微镜和小角度中子散射揭示了 KE 特有的形态变化，但在 EE 中不存在。振动光谱测量表明，Cu(II) 可以与侧链的胺部分配位，而不会直接影响主链酰胺。虽然在过量溶剂中的配位导致规则的纳米结构，样品的快速干燥产生了以低聚酰胺为模板的 CuCl2 结晶。本文报道的超分子组装体的金属配位交联是金属超分子框架结构的首次实现。图形概要