Abstract

In a number of adult tissues, Nestin-positive stem cells/progenitors have been identified and shown to be involved in maintenance and remodeling. Various studies have shown that under stressful conditions, quiescent Nestin-positive progenitor cells are activated. Thereby, they migrate to their target location and differentiate into mature cells. In the current paper, we discuss if Nestin-positive progenitors in the hippocampus and adrenal gland belong to unique cell populations that are responsive to stress. Furthermore, we speculate about the mechanism behind their activation and the clinical importance of this stress-response.

中文翻译：

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Nestin阳性细胞对压力有反应吗？

摘要

在许多成人组织中，巢蛋白阳性干细胞/祖细胞已被鉴定并显示出参与维持和重塑。各种研究表明，在压力条件下，静止的Nestin阳性祖细胞被激活。因此，它们迁移到其靶标位置并分化为成熟细胞。在本文中，我们讨论了海马和肾上腺的Nestin阳性祖细胞是否属于对压力有反应的独特细胞群。此外，我们推测了它们激活背后的机制以及这种应激反应的临床重要性。