The advanced glycation end products (AGEs) constitute a wide variety of substances synthesized from interactions between amino groups of proteins and reducing sugars, which excess induces pathogenesis of chronic diseases. Brazil is the major producer of citrus, a low-cost source of hesperidin, which is a polyphenol recognized for its capacity to inhibit AGEs formation. This is the first work to evaluate the effects of a polyphenolic fraction derived from citrus wastes on the antiglycation and on the inhibition properties of digestive enzymes on the possibility to process these wastes in high value-added products. At concentrations of 10, 15 and 20 mg/mL inhibition of AGEs was higher than 60%. The extracts were able to inhibit by 76% the activity of pancreatic lipase and by 98% the activity of α-glucosidase. For the α-amylase the inhibition capacity was lower than 50%. Strong correlation was obtained among anti-glycation with polyphenolic content and antioxidant capacity.

先进的糖基化终产物（AGEs）构成了多种多样的物质，这些物质是由蛋白质的氨基与还原糖之间的相互作用合成的，过量地诱导慢性疾病的发病机理。巴西是柑橘的主要生产国，柑橘是橙皮苷的低成本来源，橙皮苷是一种多酚，具有抑制AGEs形成的能力。这是评估源自柑橘废料的多酚馏分对抗糖化作用和消化酶抑制特性在高附加值产品中加工这些废料的可能性的影响的第一项工作。在10、15和20 mg / mL的浓度下，AGEs的抑制率高于60％。提取物能够抑制76％的胰脂肪酶活性和98％的α-葡萄糖苷酶活性。对于α-淀粉酶，抑制能力低于50％。抗糖化作用与多酚含量和抗氧化能力之间具有很强的相关性。