Abstract

A versatile, operationally simple and highly efficient protocol for the synthesis of highly functionalized piperidines have been developed by the three-component reaction of aromatic aldehydes, aromatic amines and b-ketoesters catalyzed by InBr₃ in ethanol. Also, InBr₃ is demonstrated to be an efficient catalyst for synthesis of benzo[a]pyrano[2,3-c] phenazines. The significant advantages of this protocol are highlighted by excellent yields, short reaction times, avoidance of toxic solvent and broader substrate scope.

中文翻译：

---

InBr3催化合成高官能化哌啶和苯并[a]吡喃[2,3-c]吩嗪

摘要

_{通过由 InBr 3}在乙醇中催化的芳香醛、芳香胺和 b-酮酯的三组分反应，开发了一种用于合成高度官能化哌啶的通用、操作简单且高效的方案。此外，InBr ₃被证明是合成苯并[a]吡喃并[2,3-c]吩嗪的有效催化剂。该协议的显着优势在于出色的产量、较短的反应时间、避免有毒溶剂和更广泛的底物范围。