Abstract

A convenient, commercial and simple process was developed for the synthesis of 1-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]-2-(methylselanyl)ethanol. 2-(2,7-dichloro-9H-fluoren-4-yl)oxirane was converted to 1-(2,7-dichloro-9H-fluoren-4-yl)-2-(methylselanyl)ethanol in presence of dimethyl diselenide and sodium borohydride and consequently converted to 1-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]-2- (methylselanyl)ethanol via Knoevenagel condensation with 4-chlorobenzaldehyde in presence of sodium hydroxide in reasonably good yield and purity.

中文翻译：

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高效合成具有优异 HPLC 纯度的新型 1-[(2,7-Dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]-2-(methylselanyl)ethanol 的方法

摘要

开发了一种方便、商业和简单的方法来合成 1-[2,7-二氯-9-(4-氯亚苄基) -9H-芴-4-基]-2-(甲基硒基)乙醇。在二甲基存在下， 2-(2,7-二氯-9H-芴-4-基)环氧乙烷转化为1-(2,7-二氯-9H-芴-4-基) -2- (甲基硒基)乙醇二硒化物和硼氢化钠，因此在存在的情况下通过Knoevenagel 与 4-氯苯甲醛缩合转化为 1-[2,7-二氯-9-(4-氯苯亚甲基)-9 H-芴-4-基]-2-(甲基硒基)乙醇氢氧化钠在相当好的收率和纯度。