ABSTRACT The main objective of this research was to determine and correlate the equilibrium solubility of sodium sulfadiazine in several {cosolvent (1) + water (2)} mixtures at 298.2 K. Cosolvents were formamide, N-methylformamide, N,N-dimethylformamide, dimethyl sulphoxide, N-methyl-2-pyrrolidone, 1,4-dioxane, and methanol. Classical shake-flask method was used to determine isothermal solubility. Drug concentration measurements were performed by means of electrical conductivity determinations after adequate aqueous dilutions. Solubility of sodium sulfadiazine decreases non-linearly with the addition of cosolvent to water in almost all mixtures compositions. The Jouyban-Acree and Jouyban-Acree-Abraham models correlate the solubility values with the mixtures composition for all cosolvent systems. Furthermore, the apparent specific volume of this drug at saturation was also calculated from density and mixtures compositions.

中文翻译：

---

磺胺嘧啶钠在某些水性助溶剂混合物中在 298.2 K 饱和时的平衡溶解度和表观比容

摘要 本研究的主要目的是确定磺胺嘧啶钠在 298.2 K 下几种 {助溶剂 (1) + 水 (2)} 混合物中的平衡溶解度并与之相关联。助溶剂为甲酰胺、N-甲基甲酰胺、N,N-二甲基甲酰胺、二甲基亚砜、N-甲基-2-吡咯烷酮、1,4-二恶烷和甲醇。经典摇瓶法用于测定等温溶解度。在充分的水稀释后，通过电导率测定进行药物浓度测量。在几乎所有的混合物组合物中，随着助溶剂加入水中，磺胺嘧啶钠的溶解度呈非线性降低。Jouyban-Acree 和 Jouyban-Acree-Abraham 模型将溶解度值与所有共溶剂系统的混合物组成相关联。此外，