ABSTRACT This study reports the experimental mesalazine solubility data in the binary mixtures of ethanol and water at temperature ranges of 293.2–313.2 K. The generated data are correlated with six co-solvency mathematical models including the van’t Hoff, the mixture response surface, the Yalkowsky, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, and the modified Wilson models, and the mean relative deviations (MRD%) of the back-calculated solubility for each investigated model are reported. Density of the mesalazine saturated solutions as another physicochemical property are also fitted by the Jouyban–Acree model. Moreover, standard enthalpy, entropy and Gibbs free energy changes for mesalazine dissolution process are obtained by using the van’t Hoff and Gibbs equations. Furthermore, by means of inverse Kirkwood-Buff integrals is observed that mesalazine is preferentially solvated by water in almost all the mixtures studied.

中文翻译：

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不同温度下美沙拉秦在乙醇和水的二元混合物中的溶解度

摘要 本研究报告了 293.2–313.2 K 温度范围内乙醇和水的二元混合物中美沙拉秦的实验溶解度数据。生成的数据与六个共溶解数学模型相关，包括范特霍夫、混合物响应面、报告了 Yalkowsky、Jouyban-Acree、Jouyban-Acree-van't Hoff 和修正的 Wilson 模型，以及每个研究模型的反向计算溶解度的平均相对偏差 (MRD%)。作为另一种物理化学性质的美沙拉秦饱和溶液的密度也由 Jouyban-Acree 模型拟合。此外，美沙拉秦溶解过程的标准焓、熵和吉布斯自由能变化是通过使用范特霍夫和吉布斯方程获得的。此外，