ABSTRACT The effect of solvent on the baicalin solubility was studied by making a correlation between the solubility values and solvent’s descriptors for solute–solvent and solvent–solvent interactions with the help of linear solvation energy relationship concept. The preferential solvation analysis of baicalin in the four aqueous co-solvent solutions of isopropanol, n-propanol, ethanol and methanol was carried out from solubility values through the method of inverse Kirkwood–Buff integrals. In intermediate and alcohol-rich compositions, the solvation of baicalin was preferred by the isopropanol, n-propanol, ethanol or methanol.

中文翻译：

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黄芩苷在甲醇、乙醇、异丙醇和正丙醇的水性共溶剂混合物中的溶解度：溶剂-溶剂和溶剂-溶质相互作用和 IKBI 优先溶剂化分析

摘要 借助线性溶剂化能关系概念，通过溶解度值与溶剂对溶质-溶剂和溶剂-溶剂相互作用的描述之间的相关性，研究了溶剂对黄芩苷溶解度的影响。黄芩苷在异丙醇、正丙醇、乙醇和甲醇的四种共溶剂水溶液中的优先溶剂化分析是通过逆柯克伍德-布夫积分方法从溶解度值进行的。在中间体和富含酒精的组合物中，黄芩苷的溶剂化优先于异丙醇、正丙醇、乙醇或甲醇。